Best Berberine Supplements-Top 10 brands reviewed for 2021

To help you find a good product, we are now researching and narrowing down the best berberine supplements on the market.

Top 10 berberine supplements products compared.

1. Energetic premium berberine supplement

The company makes Energetic premium berberine supplements using the highest quality berberine HCL extract.  A GMP certified factory produces this product.


1200mg berberine HCL

Made in America

FDA registered GMP certified facility

Use berberine HCL


Energetic is a premium natural supplement brand believes in the healing power of nature. Their products are all produced in GMP certified factories, and the greatest concern is for quality. They are very confident in their products, and if the product doesn’t satisfy someone, they even offer a 365-day money-back guarantee.

Bottom line:  A reliable company manufactures this product with the highest quality raw materials-it provides you with pure source berberine.

2. Thorne Research-Berberine supplements

It does not contain dairy products, eggs, nut ingredients, gluten, artificial preservatives, high fructose corn syrup and stearate.


1000mg berberine HCL

Berberine HCL Pills

Vegetarian capsule

Free of dairy products, eggs, nut ingredients, gluten and high fructose corn syrup

Free of artificial preservatives and stearates


Thorne Research is a nutritional supplement brand that has been providing consumers with high-quality nutritional supplements for 30 years. Their manufacturing facilities have NSF international certification, TGA certification and FDA GMP certification. They provide a variety of products including cardiovascular, liver, endocrine, immune, gastrointestinal, neurological and metabolic support.

3. Dr. Whitaker’s Berberine supplements

Dr. Whitaker developed Whitaker’s berberine, a pioneer in alternative medicine, and can be taken once per meal. The total daily dose of berberine supplements is 1,500 mg.


500mg Berberine HCL

Made in America

Gluten free

Formulated by Dr. Julian Whitaker

Clinical grade berberine


Dr. Whitaker is a pioneer in the field of alternative medicine. He has spent more than 40 years helping people improve their health through safe, natural supplements. He also established the Whitaker Institute for Health. Whitaker educated at Dartmouth College and received a doctorate in medicine from Emory University. His health philosophy is preventive rather than curative.

Bottom line: This product does contain more adhesive than some alternatives.

4. We are like the vitamin berberine supplements

We are like the vitamin berberine which is an affordable berberine hydrochloride HCL pill, manufactured in a GMP certified facility in the United States. It does not include artificial colors, flavors or preservatives; it does not contain yeast, corn, milk, milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.


900mg berberine HCL


Made in America

Manufactured in a GMP certified factory

No artificial colors, flavors or preservatives

Does not contain yeast, corn, milk, salt, sodium, soy, sugar, gluten, starch or wheat


We are like Vitamin is an updated supplement brand that produces 24 different vitamin, herbal and amino acid products. Their products have a 100% money-back guarantee.

5. Vitamin because you are pure berberine supplements

The company packs Vitamin, because you are  pure and highly potent berberine in gelatin quick-release berberine hydrochloride tablets. It does not contain artificial flavors, coloring agents, preservatives, yeast, corn, milk, lactose, sodium, salt, sugar, soy, gluten, starch or wheat.


900mg berberine HCL


Use berberine HCL

Free of artificial flavors, colors and preservatives

Free of corn, milk, sugar, salt, soy, yeast, gluten, starch and wheat



Use rice flour filler

Less effective than some alternatives

Reputable brand


Because vitamins are a manufacturer of 1,300 different vitamin products, the industry has a history of 50 years. They only produce supplements in capsule form and do not use chemicals or preservatives. They use rice noodles instead of fillers.

6. Swanson Berberine supplements


400mg berberine HCL


Use berberine HCL

Manufactured in a GMP certified factory


Swanson Vitamin is a supplement brand that produces a variety of dietary supplements at affordable prices. They were founded in 1969 by Leland Swanson (a golfer who was looking for his natural remedy for developing neutral arthritis). Today, Swanson sells health products for the heart, immune system, joints, probiotics, memory and brain support, vision support, anti-aging, and even beauty products.

Bottom line: This is one of the most effective berberine supplements on the market at a reasonable price. It provides you with all the benefits of berberine in a single pill. You can easily add it to your daily regimen.

7. Bulk supplements pure berberine HCL powder                                                              

This is pure berberine HCL powder. It has been laboratory tested to ensure its purity and can be purchased in bulk. You can customize the dosage because it is in powder form. It contains no sugar, soy, dairy products, yeast, gluten, corn or additives.


500mg berberine HCL


Berberine HCL powder

Free of sugar, soy, dairy products, yeast, gluten, corn and additives

Customizable berberine supplement dosage


Bulksupplements is a supplementary ingredient supplier that produces 200 pure nutrients in an FDA-registered GMP certified facility. The number of products they provide ranges from grams to metric tons to supplement companies and individual consumers! They test all their supplements for purity and quality control before leaving the facility, which ensures that their products are safe.

Bottom line: You can completely control the dose of berberine. There are no other ingredients, you can customize the dosage as needed. This is why supplementing with pure small Ber alkali hydrochloride powder in bulk is one of our choices.

8. Amazing Nutrition Amazing Formula Berberine Plus supplements

Amazing nutrition Amazing formula Berberine Plus is a berberine HCL pill that is suitable for every meal. A US GMP certified factory produces it and a 3rd party tests it to ensure quality.


500mg berberine HCL

made in America

GMP certified manufacturing plant

3rd party test

Berberine HCL Pills

Who did it

Amazing Nutrition is a supplement manufacturer that provides vitamins, herbs, omega fats, whole foods and sports nutrition supplements. A US GMP certified factory produces it.  The company lies in Jersey City, New Jersey.

Bottom line: The amazing nutritionally amazing formula Berberine Plus is a good choice, but it uses a large proportion of rice flour as a filler in the product. It is also a bit more expensive than some alternatives.

9. Integrated Therapeutics-Berberine Complex supplements

Integrated Therapeutics-Berberine Complex is a berberine formula that includes Golden Retriever and Oregon grape extract. Both Goldenseal and Oregon grapes naturally contain berberine, and other compounds can be added to the complex.


400mg barberry root extract

400mg Oregon grape extract

Including traditional herbal medicine white hair eel and Oregon grape


Integrated Therapeutics is a health supplement brand that combines the wisdom of traditional, natural therapies and alternative medicines with traditional medicines to produce comprehensive and effective health products. The brand was created in collaboration with Vitaline Formulas, NF Formulas, Tyler Encapsulations, Phytopharmica and Schwabe.

Bottom line: If you are looking for natural herbal remedies, this may be the berberine supplement for you. It also includes other antioxidants from the various berberine herbs used in this formula, making it a good anti-aging supplement. However, it is more expensive, and it does not use berberine HCL.

10. Solaray Berberine Special Formula supplements

Solaray berberine advanced formula is formulated from grape extracts from Oregon. The only other ingredient in this product is a vegetarian capsule, which means it contains no fillers!


250mg berberine HCL

285mg Oregon grape extract

Includes Oregon grape extract

Use berberine HCL

Vegetarian capsule


Solaray is a well-known health care product manufacturer established in Utah in 1973 and acquired in 1993. The company has been a pioneer in the herbal supplement industry, offering more than 1,000 herbal products.

Bottom line: This is a good choice for berberine, which also provides other antioxidant effects of Oregon grape extract. However, it is more like an Oregon grape supplement than Huanglian Pill, and its berberine dosage is lower than that of Oregon grapes. The combined dose is also low.

Frequently asked questions about berberine supplements

What is berberine?

Berberine is a compound found in many good natural sources, and it is one of the most studied natural supplements.

One of its most famous sources is the plant root of barberry, which is a shrub of different varieties that produce flowers. Berberine powder is bright yellow, similar to turmeric or curcumin.

In ancient and modern cultures, it has been used in medicine for more than 2,500 years. Today, berberine supplements come in the form of capsules, tablets, extracts, etc.

What are the uses and benefits of berberine supplements?

Berberine most well-known anti-inflammatory properties. It activates an enzyme in the cell called AMP-activated protein kinase (AMPK). Because of its regulation of body fat composition and life span, it is often called the “master switch.” When activated, this enzyme stimulates metabolic functions.

This is a natural alkaloid that can be found in various herbs. In supplement form, alkaloids have been found to have many pharmacological effects, which can provide the following benefits, including:


Berberine has shown some potential natural remedy for diabetes. In one study, found that the use of small base berberine supplements can lower blood sugar levels, this effect may help treat existing Type II diabetes, and potentially even can first reduce the risk of developing the disease. Another study found that berberine is metformin as effective, a popular diabetes drug, for controlling symptoms of type II diabetes. Berberine may also increase insulin sensitivity, which not only helps to control diabetes, but also may reduce the risk of kidney damage. More research is needed, but continuous management of diabetes is the most promising place for berberine.


Berberine may help lower high cholesterol levels, especially in patients with diabetes. One study found that the combination of berberine and red rice provides more extensive protection of cholesterol- compared with statin therapy (a common cholesterol therapy) – and a lower risk of adverse side effects. Animal studies have also found a small ber base is effective in reducing the abnormally high concentrations of fat and lipids help the liver excrete cholesterol in the blood. More research is needed, but preliminary evidence shows promise.


Berberine has been the focus of research looking for alternative methods to combat obesity. At present, clinical evidence is limited, but a study found that it can effectively reduce blood lipid levels, and it was observed that berberine can reduce blood lipids. Moderate weight loss effect in obese participants. More research is needed.

Alzheimer’s disease

Berberine may show some promise in fighting neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease. One study found that berberine has the potential neuroprotective pathways enhanced, leading researchers to believe it may help reduce the risk of neurodegenerative diseases. Although the preliminary results show promise, more research is needed.

Hearth health

Because berberine has shown promise in controlling obesity and blood sugar levels, researchers believe that it may also be beneficial to protect heart health. Berberine is believed to increase the release of nitric oxide in the body, which helps relax arteries and allows better blood flow and lower blood pressure. One study found that small ber base has a positive effect on heart health, may be beneficial to address heart failure and cardiac arrhythmias. More research is needed.

Berberine is a supplement that has shown many promises in many areas, although many aspects of its effects require more research.

Who can benefit from berberine supplements?

Those who are overweight

The metabolic benefits of berberine can help improve weight loss combined with exercise and a healthy diet. By activating the “master switch” enzyme AMPK, it can stimulate metabolism and improve people’s ability to burn energy from food-instead of storing it in fat cells. This process also helps to increase energy levels, because the food you eat is more for energy! If you are on a diet, this is crucial because your body will not be used to reduce calorie intake.

Those with cardiovascular health problems

The cardiovascular system includes veins, arteries and heart. This important system pumps nutrients and oxygen throughout the body through the blood. Many different problems can plague the system, including high blood pressure, high cholesterol, high blood sugar, etc. All these factors increase the risk of heart disease.

Those with digestive problems

Your digestive health and function may be affected by factors such as inflammation and the growth of intestinal bacteria. The immune system attacks the overgrowth of intestinal bacteria, which may cause excessive inflammation of the digestive system, making these problems coexist. Sometimes, inflammation may be a form of inflammatory bowel disease (IBD). Berberine can help balance the bacteria in the gut by killing harmful bacteria (such as Candida). It can also help support the immune system and reduce inflammation, making it a good supplement for digestive health.


Athletes who wish to lose weight and improve their body composition can benefit from taking berberine supplements. Since berberine is beneficial for weight loss, it can help athletes achieve a lower body fat composition. At the same time, it can also increase energy levels to improve athletic performance.

Are there any side effects of berberine supplements?

Berberine usually does not cause adverse side effects and is generally well tolerated. However, high doses of berberine may cause side effects such as diarrhea and stomach cramps. Berberine can also interact adversely with antibiotics, so do not use berberine in combination with antibiotics.

How do I take berberine supplements?

Due to the metabolic effects of berberine, one meal is best. For berberine supplement dosage instructions, please follow your specific supplement instructions.

There is no research on the effect of berberine on children, so it is not recommended for children.

Is there a beneficial berberine stack?

Berberine can also be stacked with other supplements to meet your needs more effectively. The more effective berberine heap has synergistic benefits, which means that each supplement is more beneficial than using it alone.

Here are some good berberine heaps:

Berberine and Quercetin

Quercetin and Berberine can promote inflammation and support the immune system. Quercetin is a plant pigment with powerful antioxidant properties and has anti-inflammatory and antihistamine effects. It is also a heart protector, which makes it a good compliment for berberine.

Berberine and Milk Thistle

Milk Thistle is an herb that has been used for 2,000 years to protect the liver from toxins and inflammation. Milk thistle and berberine make the powerful berberine stack support the immune system and digestive health, as well as detoxify and alkalize the body.

Berberine and Oregon grape and / or Goldenseal

Goldenseal and Oregon Grape both naturally contain berberine, and they add extra antioxidant binding species. It also helps strengthen the berberine benefits of the digestive system and cardiovascular system.

How do I choose a good berberine supplements product?

Berberine hydrochloride should be used to prepare high-quality berberine supplements because it is currently the most widely studied form and has been found to be the easiest to absorb.

The berberine pills and powder should also be bright yellow without artificial coloring-so you can see that the product does contain high-quality berberine.

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